Mike is blind and wants to know what computers he can use that will speak to him. Leo says all of them have accessibility features, but most use screen readers to read what's on the computer screen. The programs aren't cheap, however. JAWS is the best known.
But there are open source options like ORCA. If you're fluent in braille, a braille screen reader reads your screen and displays them on a refreshable terminal with dots that go up and down.