Mitzy has a problem with her Epson Perfection 1260 scanner and their recently bought Windows 10 computer. They just won't work together. Epson says that the model isn't supported by Windows 10. Leo says that the Windows 8 64 bit drivers may actually work. It's at least worth a try. Epson also has a scanner driver and scan utility for that model. Mitzy can also run the scanning program in Compatability Mode, which could make it work.
Lastly, there is a third party scanner driver that works with TWAIN that can work. It's called Hamrick VueScan. There's a free trial.