Brant is having an intermittent problem with his USB ports not working. He has to reboot to get them working again. Leo says it could be hardware or software. Hardware-wise, the solders could be coming off and the computer has to warm up to reseat the solder connections. The easy fix is to get a USB card to add to your system and bypass the onboard connections altogether. It could also be your computer is underpowered or your power supply is getting flakey. Try unplugging your USB items and reboot. If could also be a bad USB driver. You can try removing them and then rebooting. Windows will reinstall the drivers.