Jakai built his own super gaming and video editing computer. Now his icons are disappearing in Windows 10. Leo suggests clearing the icon cache. There's also a setting for hiding desktop icons, so that could have been enabled. Multiple monitors could also cause an issue as Windows will have issues knowing where the icons go on which monitor. Jakai should try disconnecting one monitor and see if it all goes back to normal. It may be that there's a corrupted sector on the hard drive.
Leo also recommends just deleting the icon cache and let Windows rebuild it. It could be a corrupted cache file. That can happen if there are too many files in the icon cache folder.