Chris wants to know if he can have a running backup that will enable him to reboot should the hard drive crash and just pick up right where he left off. Leo says he can do it by setting up a RAID running RAID 1. He can also run SuperDuper which can create bootable backups, but it's Mac only.
Here are a few suggestions from the chatroom:
Leo also provided more options in a segment from episode 1178, which you can find here.