Andrew wants to be able to control several monitors separately by remote, but with regular IR remotes, everything he does will affect all of the TVs. Leo says ideally he'd like to be able to do this in software without the remote. Leo says it would be nice if those monitors had a serial port for control. There are remote apps that use Wi-Fi with a phone. Openhab has some documentation for controlling TVs using a serial protocol. He'll have to check those monitors to see if they have a service port, or some sort of port that allows serial control. If it does, then he's golden. He might have the same issue, however, if he can't identify and talk to each TV uniquely.
TwistedMister in the chat room suggests checking out SimpleControl.com.